Recent meta-analyses and publications over the past 15 years have provided evidence\nshowing there are considerable gender differences in the pharmacokinetics of metoprolol. Throughout\nthis time, there have not been any research articles proposing a gender stratified dose-adjustment\nresulting in an equivalent total drug exposure. Metoprolol pharmacokinetic data was obtained\nfrom a previous publication. Data was modeled using nonlinear mixed effect modeling using the\nMONOLIX software package to quantify metoprolol concentrationââ?¬â??time data. Gender-stratified\ndosing simulations were conducted to identify equivalent total drug exposure based on a 100 mg\ndose in adults. Based on the pharmacokinetic modeling and simulations, a 50 mg dose in adult\nwomen provides an approximately similar metoprolol drug exposure to a 100 mg dose in adult men.
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